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pentobarbital will lessen the level or effect of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with sturdy CYP3A4 inducers just isn't advisedpentobarbital will lower the level or effect of oxybutynin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.pen